vsversusfinder

Logitech Signature M650 L Full Size Wireless Mouse - for Large Sized Hands vs Logitech MX Anywhere 3S Compact Wireless Mouse

Updated August 2026The Logitech Signature M650 L is a comfortable, budget-friendly option for larger hands, while the Logitech MX Anywhere 3S offers advanced features and portability for professionals.

The Logitech Signature M650 L is a comfortable, budget-friendly option for larger hands, while the Logitech MX Anywhere 3S offers advanced features and portability for professionals.

Why Logitech Signature M650 L Full Size Wireless Mouse - for Large Sized Hands is better

Price

The Signature M650 L is significantly cheaper at £34.97.

Comfort

Designed for larger hands and left-handed users.

Battery Life

Lasts up to 24 months on a single AA battery.

Why Logitech MX Anywhere 3S Compact Wireless Mouse is better

Precision

Features an 8K DPI sensor for high precision.

Multi-Device

Can connect to up to 3 devices simultaneously.

Quick Charging

Lasts up to 70 days on a full charge with quick charging capability.

Overall score

Logitech Signature M650 L Full Size Wireless Mouse - for Large Sized Hands
70
Logitech MX Anywhere 3S Compact Wireless Mouse
85

Specifications

SpecLogitech Signature M650 L Full Size Wireless Mouse - for Large Sized HandsLogitech MX Anywhere 3S Compact Wireless Mouse
BrandLogitechLogitech
ConnectivityBluetooth/USBBluetooth
DPI40008000
Battery TypeAARechargeable
Silent ClicksYesYes

Dimension comparison

Logitech Signature M650 L Full Size Wireless Mouse - for Large Sized HandsLogitech MX Anywhere 3S Compact Wireless Mouse

Design and Comfort

The Logitech Signature M650 L is designed for larger hands, offering a comfortable fit, especially for left-handed users. In contrast, the Logitech MX Anywhere 3S is compact and portable, making it ideal for users who are frequently on the move.

The Signature M650 L features a contoured shape with a soft thumb area and rubber side grips, which enhance comfort for prolonged use. This mouse also prioritises quiet operation, reducing click noise by up to 90% with its SilentTouch technology. On the other hand, the MX Anywhere 3S, while smaller, boasts a high-precision 8K DPI sensor, allowing it to track smoothly on various surfaces, including glass. Its portable design means it can easily fit into a bag, making it a great companion for those who work in various locations.

Connectivity Options

When it comes to connectivity, both mice offer versatile options, but they cater to different user needs. The Signature M650 L allows for a quick connection via Bluetooth Low Energy or a Logi Bolt USB receiver, making it compatible with a variety of devices seamlessly.

Conversely, the MX Anywhere 3S can connect to up to three devices simultaneously via Bluetooth, accommodating users who frequently switch between multiple devices. It is also engineered for Intel Evo, ensuring an optimal Bluetooth connection without the need for dongles. Both mice support Windows, macOS, and Linux, but the MX Anywhere 3S stands out with its multi-device functionality, which can be particularly useful for professionals who juggle various gadgets.

Price Point

In terms of pricing, the Logitech Signature M650 L is significantly more affordable at £34.97, while the Logitech MX Anywhere 3S is priced at £68.40. This price difference of £33.43 reflects the additional features and capabilities offered by the MX Anywhere 3S.

For users on a budget or those who require a straightforward mouse for basic tasks, the Signature M650 L presents excellent value. However, for those who need advanced features and greater functionality, the investment in the MX Anywhere 3S may be justified, especially considering its compact design and multi-device connectivity.

Functionality and Features

Both mice are equipped with features that enhance user experience, yet they cater to different functionalities. The Signature M650 L is designed for comfort and ease of use, featuring customisable side buttons that can be programmed through Logitech Options+. This allows users to tailor their mouse experience to their preferences, making repetitive tasks more efficient.

On the flip side, the MX Anywhere 3S introduces advanced scrolling capabilities with its MagSpeed scroll wheel, which can scroll 1,000 lines per second. This feature is particularly advantageous for users who work with lengthy documents or need to navigate extensive web pages. Additionally, it has a quick-charging USB-C capability, providing up to 70 days of use on a full charge. This focus on functionality makes the MX Anywhere 3S a more powerful tool for professionals who require speed and precision in their workflow.

Battery Life

Battery life is another critical consideration when choosing between these two mice. The Signature M650 L operates on a single AA battery that can last for up to 24 months, offering exceptional longevity for daily use without the need for frequent replacements.

In contrast, the MX Anywhere 3S features a rechargeable battery that can last for up to 70 days on a full charge, with the added benefit of being able to gain up to three hours of use from just a one-minute charge. While the Signature M650 L offers long-lasting performance without the need to recharge, the MX Anywhere 3S provides the convenience of quick charging, catering to users who prefer a rechargeable option.

Target Audience

The intended audience for the Logitech Signature M650 L primarily includes individuals with larger hands and those seeking a comfortable, left-handed-friendly mouse. Its design and price point make it an excellent choice for casual users and office workers who need a reliable mouse for everyday tasks.

Conversely, the Logitech MX Anywhere 3S targets professionals and frequent travellers who require a compact, versatile mouse that can perform well on various surfaces. Its advanced features, multi-device connectivity, and higher price tag make it more suitable for tech-savvy users who need a mouse that can keep pace with their demanding work environments.

Which should you buy?

Choosing between the Logitech Signature M650 L and the Logitech MX Anywhere 3S ultimately depends on your specific needs and usage scenarios. If you have larger hands, prefer a comfortable, budget-friendly mouse, and value silent operation, the Signature M650 L is an excellent choice at £34.97. However, if you require advanced features like high-precision tracking, multi-device connectivity, and quick charging capabilities for a higher price of £68.40, the MX Anywhere 3S would be the better investment. Consider how you plan to use the mouse and select the one that aligns best with your requirements.

versusfinder.com is a participant in the Amazon Services LLC Associates Programme and the Amazon EU Associates Programme. As an Amazon Associate we earn from qualifying purchases, at no extra cost to you.

Logitech Signature M650 L Full Size Wireless Mouse - for Large Sized Hands vs Logitech MX Anywhere 3S Compact Wireless Mouse | versusfinder