Anker 2.4G Wireless Vertical Ergonomic Optical vs Logitech Signature M650 L Full Size Wireless Mouse
Updated August 2026 — Anker 2.4G Wireless Vertical Ergonomic Optical wins on ergonomics, Logitech Signature M650 L Full Size Wireless Mouse wins on noise level and battery life.
The Logitech Signature M650 L offers superior features and battery life, making it the better choice despite a higher price.
Why Anker 2.4G Wireless Vertical Ergonomic Optical is better
Price
Anker is $10 cheaper than Logitech.
Ergonomics
Anker's vertical design promotes a neutral wrist position.
Weight
Anker is lighter at 3.4 oz.
Why Logitech Signature M650 L Full Size Wireless Mouse is better
Battery Life
Logitech lasts 24 months on a single AA battery.
Noise Level
Logitech features SilentTouch technology for quieter clicks.
Customization
Logitech allows extensive button customization via software.
Overall score
Specifications
| Spec | Anker 2.4G Wireless Vertical Ergonomic Optical | Logitech Signature M650 L Full Size Wireless Mouse |
|---|---|---|
| Connectivity | 2.4G USB | Bluetooth/USB |
| Silent Clicks | No | Yes |
| Customization | Limited | Extensive |
| Ergonomic Design | Yes | Yes |
| Price | $29.99 | $39.99 |
Dimension comparison
Design and Ergonomics
The Anker 2.4G Wireless Vertical Ergonomic Optical Mouse is designed with a focus on ergonomic comfort, promoting a neutral wrist position that reduces strain. In contrast, the Logitech Signature M650 L is tailored for larger hands, providing a comfortable fit with a soft thumb area and rubber side grips. The vertical design of the Anker mouse supports a handshake position, which is particularly beneficial for extended use. Meanwhile, the Logitech mouse’s classic shape allows for a more traditional grip. Both mice cater to comfort, but the Anker's unique vertical structure may appeal to those specifically seeking ergonomic solutions.
Connectivity Options
The Anker mouse offers multi-device connectivity through a 2.4G USB receiver, allowing users to connect easily to laptops, desktops, or PCs. Conversely, the Logitech Signature M650 L provides versatile connectivity options, including Bluetooth Low Energy and Logi Bolt USB receiver. This flexibility allows users to switch between devices seamlessly, making it an excellent choice for multi-taskers. While both mice ensure reliable connectivity, the Logitech’s dual options enhance its versatility, especially for users who work across various platforms.
Sensitivity and Precision
The Anker mouse features adjustable DPI settings of 800, 1200, and 1600, which provide enhanced sensitivity and precision for different tasks. This range allows users to tailor the mouse’s responsiveness to their specific needs, whether for detailed graphic work or general browsing. On the other hand, the Logitech Signature M650 L boasts its SmartWheel technology, delivering line-by-line precision for documents and a super-fast scrolling experience for web pages. This adaptive scrolling makes it suitable for heavy document users. While both mice aim for precision, the Anker focuses on DPI versatility, whereas the Logitech emphasizes scrolling efficiency.
Click Noise Levels
When it comes to noise levels, the Logitech Signature M650 L stands out with its SilentTouch technology, which reduces click noise by up to 90%. This feature is ideal for users who need to maintain focus in quiet environments, such as offices or libraries. The Anker mouse does not specifically highlight its noise levels, which may suggest it does not provide the same level of quiet operation. For those prioritizing a silent working experience, the Logitech mouse is the clear winner in this category.
Battery Life
The Anker mouse operates on two AAA batteries, which are not included, and offers energy-efficient features that put it into power-saving mode after 8 minutes of inactivity. The Logitech Signature M650 L excels with a 24-month battery life on a single AA battery, providing a hassle-free experience without frequent battery changes. This significant difference means users of the Logitech can enjoy a longer uninterrupted usage period, making it the more convenient choice for those who prefer minimal maintenance.
Customization Features
Customization is a strong point for the Logitech Signature M650 L, as it allows users to personalize side buttons using Logitech Options+ software. This feature enables shortcuts for commonly used functions, enhancing productivity. The Anker mouse includes next/previous buttons for easier browsing, but it lacks the extensive customization options available with the Logitech mouse. Users looking for a tailored experience will likely prefer the Logitech for its added flexibility in customizing button functions.
Price Comparison
The Anker 2.4G Wireless Vertical Ergonomic Optical Mouse is priced at $29.99, making it about 25% cheaper than the Logitech Signature M650 L, which retails for $39.99. This price difference could be significant for budget-conscious users seeking a reliable mouse without compromising on ergonomic features. However, while the Anker offers value, the Logitech’s additional features and longer battery life may justify the higher price for some users.
Which should you buy?
Choosing between the Anker 2.4G Wireless Vertical Ergonomic Optical Mouse and the Logitech Signature M650 L ultimately depends on individual preferences and needs. If you prioritize ergonomics and a lower price point, the Anker mouse may be the better choice. However, if you require versatile connectivity, quiet operation, and a longer battery life, the Logitech mouse stands out despite its higher cost. Both mice offer unique benefits, making them suitable for different types of users.

