vsversusfinder

Logitech MX Anywhere 3S Compact Wireless Mouse, vs Logitech Signature M650 L Full Size Wireless Mouse

Updated August 2026 — Logitech MX Anywhere 3S Compact Wireless Mouse, wins on scrolling and comfort, Logitech Signature M650 L Full Size Wireless Mouse wins on noise level and customization.

The Logitech MX Anywhere 3S offers advanced features and portability, while the Signature M650 L excels in comfort and battery life. Choose based on your specific needs.

Why Logitech MX Anywhere 3S Compact Wireless Mouse, is better

Advanced Features

8K DPI sensor and fast scrolling

Portability

Compact design for on-the-go use

Multi-Device

Connects to up to 3 devices simultaneously

Why Logitech Signature M650 L Full Size Wireless Mouse is better

Comfort

Ergonomic design for larger hands

Battery Life

24-month battery on a single AA

Noise Level

90% less click noise with SilentTouch

Overall score

Logitech MX Anywhere 3S Compact Wireless Mouse,
85
Logitech Signature M650 L Full Size Wireless Mouse
75

Specifications

SpecLogitech MX Anywhere 3S Compact Wireless Mouse,Logitech Signature M650 L Full Size Wireless Mouse
Scroll Speed1000 lines/secLine-by-line
ConnectivityBluetooth, USBBluetooth, USB
RechargeableYesNo
CompatibilityMulti-OSMulti-OS
Custom ButtonsYesYes

Dimension comparison

Logitech MX Anywhere 3S Compact Wireless Mouse,Logitech Signature M650 L Full Size Wireless Mouse

Overview

When it comes to wireless mice, the Logitech MX Anywhere 3S Compact Wireless Mouse and the Logitech Signature M650 L Full Size Wireless Mouse cater to different user needs and preferences. The MX Anywhere 3S is designed for portability and precision, while the Signature M650 L focuses on comfort for larger hands. Understanding these differences can help you choose the right mouse for your setup.

Price Comparison

The Logitech Signature M650 L is priced at $39.99, making it about 50% less expensive than the Logitech MX Anywhere 3S, which retails for $79.99. This significant price difference may influence your choice, especially if you're on a budget. While the MX Anywhere 3S offers advanced features like an 8K DPI sensor and fast scrolling, the Signature M650 L provides solid performance for general use, making it a cost-effective option for users who prioritize value over high-end specifications.

Design and Ergonomics

The MX Anywhere 3S features a compact design that is ideal for on-the-go use, while the Signature M650 L is tailored for larger hands, providing a more comfortable grip for prolonged use. The ergonomic shape of the Signature M650 L, along with its soft thumb area and rubber side grips, enhances comfort during extended periods of use. In contrast, the MX Anywhere 3S is lightweight at only 99 grams, making it easy to carry. However, users with larger hands may find the compact size of the MX Anywhere 3S less suitable for long hours of work.

Connectivity Options

Both the MX Anywhere 3S and Signature M650 L offer versatile connectivity options. The MX Anywhere 3S can connect via Bluetooth or a Logi Bolt USB receiver (not included), allowing for seamless use across multiple devices and operating systems like Windows, macOS, and Linux. Meanwhile, the Signature M650 L also supports Bluetooth Low Energy and the Logi Bolt USB receiver, making it compatible with various platforms, including Chrome OS and iPadOS. This flexibility ensures that both mice can easily integrate into diverse setups, but the MX Anywhere 3S stands out with its ability to connect to up to three devices simultaneously.

Features and Functionality

The Logitech MX Anywhere 3S is equipped with advanced features such as an 8K DPI sensor that allows for precise tracking on any surface, even glass. It also boasts a MagSpeed scroll wheel that can scroll 1,000 lines per second. In contrast, the Signature M650 L offers line-by-line scrolling precision and the innovative SmartWheel, which automatically switches between precise and fast scrolling modes. While the MX Anywhere 3S targets high-precision needs, the Signature M650 L focuses on user-friendly features that enhance productivity, making it suitable for a range of tasks.

Battery Life

Battery life is an essential consideration for wireless mice. The Signature M650 L excels with its impressive 24-month battery life on a single AA battery, which is particularly advantageous for users who prefer a hassle-free experience. In comparison, the MX Anywhere 3S features a rechargeable battery that lasts up to 70 days on a full charge, along with a quick charge capability that provides three hours of use from just a one-minute charge. While the Signature M650 L offers long-term reliability, the MX Anywhere 3S provides flexibility with its rechargeable battery, catering to different user preferences.

Noise Level

For those who work in quiet environments, the noise level of a mouse can be a crucial factor. The Signature M650 L utilizes Logitech’s SilentTouch technology, which reduces click noise by up to 90%, making it ideal for shared workspaces. The MX Anywhere 3S also features Quiet Clicks, designed to minimize noise without sacrificing the satisfying feel of clicking. Both mice offer a quieter experience compared to traditional models, but the Signature M650 L is specifically engineered for users who require a silent operation, making it a better choice for noise-sensitive environments.

Compatibility

Both the Logitech MX Anywhere 3S and Signature M650 L boast broad compatibility, supporting major operating systems such as Windows, macOS, Linux, Chrome OS, and Android. However, the MX Anywhere 3S is particularly versatile, allowing users to switch between up to three devices seamlessly. This feature is ideal for professionals who frequently toggle between computers or devices. While the Signature M650 L is compatible with a range of systems and is certified for Chromebook, it does not offer the same level of multi-device connectivity, which may be a deciding factor for some users.

Which should you buy?

Choosing between the Logitech MX Anywhere 3S and the Logitech Signature M650 L ultimately depends on your specific needs. If you require a compact mouse with advanced features for precise work and the ability to connect to multiple devices, the MX Anywhere 3S is worth the investment at $79.99. However, if you prioritize comfort, extended battery life, and a quieter operation, the Signature M650 L is an excellent choice for just $39.99. Both mice have their strengths, making them suitable for different types of users and scenarios.