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Logitech MX Ergo S Advanced Wireless Trackball vs Logitech Signature M650 L Full Size Wireless Mouse

Updated August 2026 — Logitech MX Ergo S Advanced Wireless Trackball wins on customization and comfort, Logitech Signature M650 L Full Size Wireless Mouse wins on value and noise.

The Logitech MX Ergo S offers advanced ergonomic features and customization, while the Signature M650 L is a budget-friendly option with essential functionality. Choose based on your needs.

Why Logitech MX Ergo S Advanced Wireless Trackball is better

Ergonomics

MX Ergo S reduces forearm strain by 27%.

Customization

MX Ergo S has 6 programmable buttons.

Rechargeable

MX Ergo S offers USB-C charging.

Why Logitech Signature M650 L Full Size Wireless Mouse is better

Price

Signature M650 L is 60% cheaper.

Battery Life

Signature M650 L lasts 24 months on AA.

Noise Level

Signature M650 L has 90% less click noise.

Overall score

Logitech MX Ergo S Advanced Wireless Trackball
85
Logitech Signature M650 L Full Size Wireless Mouse
70

Specifications

SpecLogitech MX Ergo S Advanced Wireless TrackballLogitech Signature M650 L Full Size Wireless Mouse
Price$99.99$39.99
Battery TypeRechargeableAA
Click Noise80% quieter90% quieter
Programmable Buttons62
Tilt Angle20 degreesN/A

Dimension comparison

Logitech MX Ergo S Advanced Wireless TrackballLogitech Signature M650 L Full Size Wireless Mouse

Design and Ergonomics

The Logitech MX Ergo S Advanced Wireless Trackball Mouse is designed for maximum comfort with its sculpted ergonomic shape and a 20-degree tilt that reduces forearm strain by 27%. This mouse is especially beneficial for those who spend long hours at their computer, as it is certified by ergonomists. In contrast, the Logitech Signature M650 L Full Size Wireless Mouse provides a comfortable grip with a soft thumb area and rubber side grips, making it suitable for large hands. While both mice focus on comfort, the MX Ergo S's unique trackball design offers a different approach to ergonomic use, emphasizing reduced hand movement.

Connectivity Options

The Logitech MX Ergo S offers versatile connectivity options with Bluetooth and a Logi Bolt USB receiver, allowing you to switch between two devices seamlessly. This flexibility is ideal for users who work across multiple computers or devices. The Logitech Signature M650 L also provides dual connectivity, supporting Bluetooth Low Energy and a Logi Bolt USB receiver. However, the MX Ergo S stands out with its Easy-Switch button, enabling quicker transitions between devices compared to the standard pairing process of the Signature M650 L.

Battery Life and Charging

The MX Ergo S boasts an impressive battery life, lasting up to 120 days on a full charge, with the added benefit of quick charging—just one minute of charging provides up to 24 hours of use. This makes it an advantageous option for users who may forget to charge their devices regularly. On the other hand, the Logitech Signature M650 L offers a 24-month battery life on a single AA battery, which is significantly longer but requires occasional battery replacements. For those who prefer rechargeable options, the MX Ergo S provides a more convenient solution with its USB-C charging capability.

Customization and Functionality

The Logitech MX Ergo S features six customizable buttons that can be programmed through the Logi Options+ app, allowing users to create shortcuts and streamline their workflow. This enhances productivity significantly, particularly for users who rely on specific tasks or functions during their workday. The Signature M650 L also includes customizable side buttons, but it is less advanced in terms of the number of programmable options. Both mice cater to personalization, but the MX Ergo S provides a broader range of customization, which could be a deciding factor for power users.

Noise Levels

The MX Ergo S is designed with quieter clicks, claiming to reduce noise by 80%, making it suitable for quiet environments like offices or libraries. This feature allows users to work without disturbing those around them. Similarly, the Signature M650 L incorporates SilentTouch technology, which claims to reduce click noise by 90%. While both products prioritize a quieter experience, the Signature M650 L may appeal to users who are particularly sensitive to sound, offering an even quieter alternative.

Price Point

The Logitech MX Ergo S is priced at $99.99, making it a premium choice for users seeking advanced ergonomic features and customization capabilities. In contrast, the Signature M650 L is considerably more affordable at $39.99, approximately 60% less expensive than the MX Ergo S. For budget-conscious consumers or those who do not require advanced functionalities, the Signature M650 L presents a compelling option without sacrificing essential features.

Target Audience

The MX Ergo S is primarily aimed at users who prioritize ergonomics and comfort in their computing experience, especially those who work long hours or suffer from wrist strain. Its advanced features and customizable buttons make it an excellent fit for professionals and gamers alike. Conversely, the Signature M650 L is better suited for casual users or those with larger hands looking for a reliable, comfortable mouse without the need for high-end features. Its affordability and easy connectivity make it a good choice for everyday tasks.

Which should you buy?

In conclusion, choosing between the Logitech MX Ergo S Advanced Wireless Trackball Mouse and the Logitech Signature M650 L Full Size Wireless Mouse largely depends on your specific needs and budget. If you prioritize advanced ergonomics, extensive customization, and rechargeable convenience, the MX Ergo S is worth the investment. However, if you seek a more budget-friendly option that offers comfort and essential features, the Signature M650 L is a solid choice. Ultimately, both mice cater to different user preferences and requirements, making them excellent options in the computer mouse market.