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Brooks Women’s Glycerin 21 Neutral Running Shoe - vs Topo Athletic Women's Magnifly 5 Comfortable

Updated August 2026 — Brooks Women’s Glycerin 21 Neutral Running Shoe - wins on cushioning and fit, Topo Athletic Women's Magnifly 5 Comfortable wins on breathability and weight.

The Brooks Women’s Glycerin 21 excels in cushioning and comfort, while the Topo Athletic Women’s Magnifly 5 offers versatility and a lower price. Choose based on your priorities.

Why Brooks Women’s Glycerin 21 Neutral Running Shoe - is better

Cushioning

Superior nitrogen-infused DNA Loft v3 cushioning

Fit

Plush internal stretch bootie for a snug fit

Support

APMA Seal of Acceptance for neutral support

Why Topo Athletic Women's Magnifly 5 Comfortable is better

Price

About 17% cheaper than Brooks

Weight

Lighter construction for easier wear

Versatility

Excels in daily mileage and recovery runs

Overall score

Brooks Women’s Glycerin 21 Neutral Running Shoe -
88
Topo Athletic Women's Magnifly 5 Comfortable
76

Specifications

SpecBrooks Women’s Glycerin 21 Neutral Running Shoe -Topo Athletic Women's Magnifly 5 Comfortable
Price$114.95$99.94
Sales Rank2988130146
Drop10mm0mm
UpperWarp knitRecycled mesh
MidsoleDNA Loft v3ZipFoam

Dimension comparison

Brooks Women’s Glycerin 21 Neutral Running Shoe -Topo Athletic Women's Magnifly 5 Comfortable

Overview of the Brooks Women’s Glycerin 21

The Brooks Women’s Glycerin 21 is priced at $114.95 and is designed for runners seeking exceptional cushioning. This shoe stands out for its plush internal fit and soft transitions, making it an excellent choice for those who prioritize comfort during their runs. With a bestseller rank of 29,881, it's a popular option among runners who appreciate a shoe that provides both support and softness.

The Glycerin 21 features nitrogen-infused DNA Loft v3 cushioning, which enhances its lightweight and responsive qualities. Additionally, the engineered warp knit upper offers breathability and flexibility, ensuring that the shoe accommodates the foot's natural movements. This model has been granted the APMA Seal of Acceptance, indicating its suitability for neutral support runners.

Overview of the Topo Athletic Women’s Magnifly 5

The Topo Athletic Women’s Magnifly 5 is priced at $99.94, making it about 17% cheaper than the Brooks model. This shoe is highly versatile, excelling in daily mileage, recovery runs, and comfortable walking. With a bestseller rank of 30,146, it appeals to those looking for a lightweight and cushioned option.

Constructed with a recycled mesh upper, the Magnifly 5 prioritizes breathability, contributing to its lightweight feel. The innovative ZipFoam midsole enhances responsiveness, providing a softer ride. Additionally, the 0mm drop design promotes a natural stride, making this shoe ideal for runners who prefer a flat platform.

Comfort and Cushioning

In terms of comfort and cushioning, the Brooks Women’s Glycerin 21 offers superior plushness with its nitrogen-infused DNA Loft v3 cushioning. This advanced technology is designed for maximum comfort, making it perfect for long runs or extended wear. The internal stretch bootie adds to the comfort by providing a snug fit that adapts to the runner's foot, ensuring that each stride feels soft and supported.

On the other hand, the Topo Athletic Women’s Magnifly 5 also emphasizes comfort, but with a different approach. Its ZipFoam midsole provides a lighter and softer ride compared to traditional cushioning. While it may not match the plushness of the Glycerin 21, its 0mm drop design encourages a more natural running gait, which many runners find comfortable, especially for shorter distances or recovery runs.

Breathability and Fit

The Brooks Women’s Glycerin 21 features a breathable upper that enhances comfort during runs, but it is primarily focused on providing a plush fit. The engineered warp knit upper allows for flexibility, ensuring that the shoe accommodates various foot shapes and movements. This construction is ideal for runners who prefer a snug yet adaptable fit.

Conversely, the Topo Athletic Women’s Magnifly 5 excels in breathability due to its recycled mesh upper. This design not only enhances ventilation but also contributes to the shoe's lightweight feel. Runners who prioritize a cool and airy sensation during their runs may find the Magnifly 5 more appealing, especially in warmer conditions.

Versatility in Use

When it comes to versatility, the Brooks Women’s Glycerin 21 is suitable for road running, cross-training, and gym activities. Its neutral support and maximum cushioning make it a great choice for a variety of activities, allowing runners to transition seamlessly from the road to the gym.

The Topo Athletic Women’s Magnifly 5 is designed for multiple purposes as well. Its ability to excel in daily mileage, recovery runs, and leisurely walks makes it a practical choice for those who want a single shoe for various activities. The combination of comfort and responsiveness ensures that it can handle both casual outings and more intense running sessions.

Price Comparison

The Brooks Women’s Glycerin 21 is priced at $114.95, while the Topo Athletic Women’s Magnifly 5 is available for $99.94. This price difference of approximately $15 means that the Topo Athletic shoe is about 17% cheaper than the Brooks model. For budget-conscious runners or those looking for a good deal, the Magnifly 5 presents a compelling option without sacrificing essential features.

However, the price difference also reflects the different technologies and cushioning systems each shoe employs. While the Brooks model offers advanced cushioning and a plush fit, the Topo Athletic focuses on responsiveness and natural movement, appealing to different runner preferences.

Performance and Durability

The Brooks Women’s Glycerin 21 is built for durability and consistent performance. Its advanced cushioning technology is designed to withstand long runs while maintaining comfort. The shoe's broad platform stabilizes the foot, promoting smooth transitions during various phases of a run, ensuring that it performs well over time.

The Topo Athletic Women’s Magnifly 5, made with a focus on lightweight construction and responsiveness, also promises durability. The ZipFoam midsole is engineered to provide a soft ride while maintaining its structure over extended use. While it may not offer the same level of plushness, its design encourages a biomechanically sound gait, which can enhance performance during runs.

Which should you buy?

Choosing between the Brooks Women’s Glycerin 21 and the Topo Athletic Women’s Magnifly 5 ultimately depends on your specific needs as a runner. If you prioritize maximum cushioning and a plush fit, the Glycerin 21 is an excellent choice, albeit at a higher price point of $114.95. However, if you're looking for a more versatile and budget-friendly option that offers comfort and responsiveness, the Magnifly 5, priced at $99.94, is about 17% cheaper and provides solid performance for various activities. Each shoe has its strengths, so consider your running style and preferences to make the best decision.