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New Balance Women's Fresh Foam X vs Brooks Women’s Glycerin 22 Neutral

Updated April 2026 — New Balance Women's Fresh Foam X wins on certification and value, Brooks Women’s Glycerin 22 Neutral wins on sustainability and fit.

Winner
Brooks Women’s Glycerin 22 Neutral Running Shoe - White/Limpet Shell/Amparo Blue - 8.5 Medium$114.95

Brooks Women’s Glycerin 22 Neutral Running Shoe - White/Limpet Shell/Amparo Blue - 8.5 Medium

Brooks

New Balance Women's Fresh Foam X 1080 V14 Running Shoe, Black/Phantom/Sea Salt, 9 M$129.99

New Balance Women's Fresh Foam X 1080 V14 Running Shoe, Black/Phantom/Sea Salt, 9 M

New Balance

The New Balance Women's Fresh Foam X offers superior value with a lower price point and significant health certifications, including the PDAC A5500 Diabetic shoe status. While the Brooks Women's Glycerin 22 Neutral counters with eco-friendly bio-based materials and a gusseted tongue, the former's combination of accommodating fit and certified support makes it the pragmatic choice for runners prioritizing comfort and budget.

Why New Balance Women's Fresh Foam X is better

New Balance Women's Fresh Foam X provides certified diabetic support

PDAC A5500 Diabetic shoe certified

New Balance Women's Fresh Foam X offers better pricing

$114.95 vs $129.99

New Balance Women's Fresh Foam X features advanced knit upper

Double jacquard knit upper

Why Brooks Women’s Glycerin 22 Neutral is better

Brooks Women's Glycerin 22 Neutral incorporates renewable resources

Approx. 3% bio-based content

Brooks Women's Glycerin 22 Neutral prevents debris entry

Gusseted tongue design

Brooks Women's Glycerin 22 Neutral ensures seamless construction

No-sew overlays

Overall score

New Balance Women's Fresh Foam X
92
Brooks Women’s Glycerin 22 Neutral
89

Specifications

SpecNew Balance Women's Fresh Foam XBrooks Women’s Glycerin 22 Neutral
Price$114.95$129.99
Midsole TechnologyDNA Tuned CushionFresh Foam X midsole foam
Upper MaterialDouble jacquard knitSynthetic and engineered mesh
Support TypeNeutralNeutral
CertificationPDAC A5500 Diabetic, APMA SealNot listed
Tongue DesignStandardGusseted
SustainabilityNot listedApprox. 3% bio-based content
PredecessorGlycerin 21Not listed

Dimension comparison

New Balance Women's Fresh Foam XBrooks Women’s Glycerin 22 Neutral

Introduction and Model Overview

When evaluating high-performance neutral running shoes, the New Balance Women's Fresh Foam X and the Brooks Women's Glycerin 22 Neutral present distinct advantages for different types of runners. Both models aim to deliver maximum cushioning and comfort, yet they approach this goal through divergent technological frameworks. The New Balance Women's Fresh Foam X emphasizes certified support and accommodating fit technologies, positioning itself as a versatile option for road running and cross-training. In contrast, the Brooks Women's Glycerin 22 Neutral focuses on sustainable materials and debris protection features. This comparison analyzes the specific features, pricing, and structural elements of both shoes to determine which offers the superior package for daily training.

Midsole Cushioning Technology

The core of any running shoe lies in its midsole, and both contenders offer proprietary solutions designed to balance softness with energy return. The New Balance Women's Fresh Foam X utilizes DNA Tuned Cushion technology. This cutting-edge system integrates dual-size cells, with larger cells in the heel to provide soft, plush landings. Smaller cells in the forefoot invite responsive toe-offs, ensuring smooth transitions during the gait cycle. Conversely, the Brooks Women's Glycerin 22 Neutral employs Fresh Foam X midsole foam. This formulation is designed to deliver a highly cushioned experience for incredible comfort. While both technologies aim for a plush ride, the cell-specific tuning in the former offers a more segmented approach to impact absorption compared to the uniform foam experience of the latter.

Upper Construction and Materials

Durability and breathability are dictated by the upper construction. The New Balance Women's Fresh Foam X features a newly engineered double jacquard knit upper. This material choice is selected to deliver a flexible and accommodating fit, combining durability with exceptional breathability. The knit structure allows the shoe to adapt to the foot's shape during movement. On the other hand, the Brooks Women's Glycerin 22 Neutral utilizes a synthetic and engineered mesh upper. This construction is paired with no-sew overlays, which reduce potential irritation points caused by stitching. While the knit upper offers superior flexibility, the engineered mesh with overlays provides a structured feel that may appeal to runners preferring a locked-down sensation.

Fit and Closure Systems

A secure fit is essential for preventing blisters and ensuring stability. The New Balance Women's Fresh Foam X relies on its accommodating fit design derived from the knit upper to secure the foot. The flexibility of the material allows for natural swelling during long runs. The Brooks Women's Glycerin 22 Neutral features an adjustable lace closure for a customized fit. Additionally, it includes a gusseted tongue designed to help keep debris out. This specific feature is advantageous for trail runners or those running in dusty environments, as it prevents small particles from entering the shoe and causing discomfort. The gusseted tongue adds a layer of practicality that the standard tongue configuration may lack.

Support and Stability Classification

Both shoes are categorized under neutral support, making them suitable for runners who do not require additional correction for overpronation. The New Balance Women's Fresh Foam X provides neutral support while offering the maximum amount of cushioning. It is ideal for road running, cross training, the gym, or wherever you might want to take them. The listing notes that those seeking the same style with added support should look for the GTS variant. Similarly, the Brooks Women's Glycerin 22 Neutral is designed for neutral runners seeking soft landings. Neither shoe introduces medial posts or guide rails, prioritizing natural foot movement over corrective stability mechanisms. This makes both options viable for runners with efficient biomechanics.

Health Certifications and Standards

One significant differentiator in this comparison is the presence of health-related certifications. The New Balance Women's Fresh Foam X is a certified PDAC A5500 Diabetic shoe and has been granted the APMA Seal of Acceptance. These certifications indicate that the shoe meets specific standards for therapeutic footwear, accommodating sensitive feet and reducing pressure points. This makes it a viable option for individuals with diabetes or specific foot conditions requiring Medicare-eligible footwear. The Brooks Women's Glycerin 22 Neutral does not list equivalent certifications in its provided features. For runners requiring documented therapeutic benefits, the certified status of the former provides a clear functional advantage.

Sustainability and Environmental Impact

Environmental considerations are increasingly important in footwear manufacturing. The Brooks Women's Glycerin 22 Neutral highlights its use of Fresh Foam X midsole foam with approximately 3% bio-based content. This bio-based content is made from renewable resources to help reduce the carbon footprint of these road running shoes. This initiative demonstrates a commitment to enhancing sustainability through material science. The New Balance Women's Fresh Foam X does not explicitly list bio-based content or carbon footprint reduction metrics in the provided data. For eco-conscious consumers, the renewable resource integration in the Brooks model offers a tangible benefit regarding environmental impact.

Price Analysis and Value Verdict

Finally, the cost-to-feature ratio plays a crucial role in the purchasing decision. The New Balance Women's Fresh Foam X is priced at $114.95, while the Brooks Women's Glycerin 22 Neutral is listed at $129.99. Given that the former includes diabetic certifications and advanced knit technology at a lower price point, it presents a stronger value proposition. The Brooks Women's Glycerin 22 Neutral commands a premium, potentially justified by its sustainability features and gusseted tongue, but the price difference is significant. Considering the combination of lower cost, certified health standards, and accommodating fit, the New Balance Women's Fresh Foam X edges out the competition for overall value.