Brooks Women’s Glycerin 22 Neutral vs Brooks Women’s Glycerin GTS 22
Updated April 2026 — Brooks Women’s Glycerin 22 Neutral wins on certification and versatility, Brooks Women’s Glycerin GTS 22 wins on support and value.
$114.95Brooks Women’s Glycerin 22 Neutral Running Shoe - White/Limpet Shell/Amparo Blue - 8.5 Medium
Brooks
$114.95Brooks Women’s Glycerin GTS 22 Supportive Running Shoe - White/Limpet Shell/Amparo Blue - 8.5 Medium
Brooks
The {{PRODUCT_B_NAME}} edges out the {{PRODUCT_A_NAME}} for runners requiring additional stability, as it includes the GuideRails support system at the same price point of $114.95. While the {{PRODUCT_A_NAME}} offers excellent neutral cushioning and holds the APMA Seal of Acceptance, the {{PRODUCT_B_NAME}} provides holistic support to keep excess movement in check without sacrificing the plush DNA Tuned cushioning found in both models.
Why Brooks Women’s Glycerin 22 Neutral is better
{{PRODUCT_A_NAME}} provides dedicated neutral support
Predecessor: Glycerin 21
{{PRODUCT_A_NAME}} holds APMA Seal of Acceptance
PDAC A5500 certified
{{PRODUCT_A_NAME}} offers exceptional breathability
Price: $114.95
Why Brooks Women’s Glycerin GTS 22 is better
{{PRODUCT_B_NAME}} includes GuideRails support system
Predecessor: Glycerin GTS 21
{{PRODUCT_B_NAME}} keeps excess movement in check
PDAC A5500 certified
{{PRODUCT_B_NAME}} is the more supportive version
Price: $114.95
Overall score
Specifications
| Spec | Brooks Women’s Glycerin 22 Neutral | Brooks Women’s Glycerin GTS 22 |
|---|---|---|
| Price | $114.95 | $114.95 |
| Support Type | Neutral Support | GuideRails Support |
| Midsole Technology | DNA Tuned | DNA Tuned |
| Upper Material | Double jacquard knit | Double jacquard knit |
| Certifications | PDAC A5500, APMA Seal | PDAC A5500 |
| Predecessor Model | Glycerin 21 | Glycerin GTS 21 |
| Recommended Use | Road running, cross training, gym | Road running, cross training, gym |
| Breathability Claim | Exceptional breathability | null |
Dimension comparison
Design and build quality
Both the {{PRODUCT_A_NAME}} and the {{PRODUCT_B_NAME}} share a foundational design language characteristic of the Brooks Glycerin line. They utilize a newly engineered double jacquard knit upper that aims to deliver a flexible and accommodating fit. This construction method combines durability with exceptional breathability, particularly noted in the {{PRODUCT_A_NAME}} documentation. The build quality is designed to withstand various activities, from road running to cross-training sessions in the gym. While the external aesthetics are similar, the internal structural differences define their specific use cases.
Cushioning technology
At the heart of both shoes lies the DNA Tuned cushion technology. This cutting-edge midsole technology seamlessly blends and integrates dual-size cells to ensure a balance of luxurious cushioning and energetic toe-offs. The design incorporates larger cells in the heel to provide soft, plush landings, while smaller cells in the forefoot invite responsive toe-offs. This configuration is identical in both the {{PRODUCT_A_NAME}} and the {{PRODUCT_B_NAME}}, ensuring that regardless of the support level chosen, the user receives the same high level of impact protection and energy return during their stride.
Support and stability features
The primary differentiator between these two models is the support system. The {{PRODUCT_A_NAME}} provides neutral support, making it ideal for runners who do not require correction for overpronation. In contrast, the {{PRODUCT_B_NAME}} features the innovative GuideRails holistic support system. This technology supports the body in its natural motion path while keeping excess movement in check. The {{PRODUCT_B_NAME}} is explicitly described as the more supportive version of the Glycerin 22, helping stabilization for those who need excess motion kept at bay.
Fit and upper construction
Fit is crucial for running performance and comfort. Both models utilize the newly engineered double jacquard knit upper to deliver a flexible and accommodating fit. The {{PRODUCT_A_NAME}} documentation highlights that this upper combines durability with exceptional breathability. While the {{PRODUCT_B_NAME}} shares the same upper engineering, its internal fit may feel slightly different due to the presence of the GuideRails support system which interacts with the foot differently during motion. Both are designed to accommodate a wide range of foot shapes within their respective support categories.
Certification and health standards
Health and safety certifications are significant for users with specific medical needs. The {{PRODUCT_A_NAME}} is a certified PDAC A5500 Diabetic shoe and has been granted the APMA Seal of Acceptance. The {{PRODUCT_B_NAME}} is also a certified PDAC A5500 Diabetic shoe. These certifications indicate that both shoes meet rigorous standards for therapeutic footwear, making them suitable for individuals with diabetes who require specific accommodation and protection for their feet during physical activity.
Versatility and use cases
Both shoes are designed for versatility beyond just running. They are ideal for road running, cross training, the gym, or wherever you might want to take them. The {{PRODUCT_A_NAME}} is suited for those seeking maximum cushioning with neutral support. The {{PRODUCT_B_NAME}} offers the same versatility but adds the capability to handle stability needs. Whether used for high-impact running or lower-impact gym sessions, both models provide the DNA Tuned cushioning necessary for smooth transitions and comfort across different surfaces and activities.
Price and value proposition
Pricing is identical for both models, with each listed at $114.95. This price point positions them as premium neutral and stability cushioned shoes. The {{PRODUCT_A_NAME}} offers value through its APMA Seal and neutral design, while the {{PRODUCT_B_NAME}} offers value by including the GuideRails technology at no additional cost over the neutral version. For runners who need stability, the {{PRODUCT_B_NAME}} represents a higher value due to the added technology. For neutral runners, the {{PRODUCT_A_NAME}} provides the same cushioning experience without unnecessary support structures.
Which one should you buy?
Choosing between the {{PRODUCT_A_NAME}} and the {{PRODUCT_B_NAME}} depends primarily on your support needs. If you have a neutral gait and do not experience excess motion during your run, the {{PRODUCT_A_NAME}} is the appropriate choice, offering the APMA Seal of Acceptance and exceptional breathability. However, if you require stabilization to keep excess movement in check, the {{PRODUCT_B_NAME}} is the superior option. It provides the same luxurious DNA Tuned cushioning and $114.95 price point but includes the GuideRails support system to help maintain your natural motion path.