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Brooks Women’s Glycerin GTS 22 vs Brooks Women’s Glycerin 23 Neutral

Updated April 2026 — Brooks Women’s Glycerin GTS 22 wins on certification and upper comfort, Brooks Women’s Glycerin 23 Neutral wins on price and support.

Brooks Women’s Glycerin 23 Neutral Running Shoe - White/Phantom/Cyber Pink - 8.5 Medium$159.99

Brooks Women’s Glycerin 23 Neutral Running Shoe - White/Phantom/Cyber Pink - 8.5 Medium

Brooks

Winner
Brooks Women’s Glycerin GTS 22 Supportive Running Shoe - White/Limpet Shell/Amparo Blue - 8.5 Medium$114.95

Brooks Women’s Glycerin GTS 22 Supportive Running Shoe - White/Limpet Shell/Amparo Blue - 8.5 Medium

Brooks

The Brooks Women's Glycerin 23 Neutral offers better value at a lower price point while providing specialized support features, whereas the Brooks Women's Glycerin GTS 22 commands a premium for enhanced upper construction and additional certifications. Runners prioritizing budget and support mechanisms may prefer the former, while those seeking maximum cushioning details and medical seals might choose the latter.

Why Brooks Women’s Glycerin GTS 22 is better

Brooks Women's Glycerin GTS 22 features a triple jacquard warp-knit upper

Triple layer construction vs double

Brooks Women's Glycerin GTS 22 includes APMA Seal of Acceptance

Additional certification over base model

Brooks Women's Glycerin GTS 22 offers upgraded forefoot cushioning

2mm more cushioning in forefoot

Why Brooks Women’s Glycerin 23 Neutral is better

Brooks Women's Glycerin 23 Neutral is significantly more affordable

$114.95 vs $159.99

Brooks Women's Glycerin 23 Neutral includes GuideRails support system

Holistic support system included

Brooks Women's Glycerin 23 Neutral provides better price-to-feature ratio

Lower cost with support tech

Overall score

Brooks Women’s Glycerin GTS 22
85
Brooks Women’s Glycerin 23 Neutral
88

Specifications

SpecBrooks Women’s Glycerin GTS 22Brooks Women’s Glycerin 23 Neutral
Price$159.99$114.95
Intended UseNeutral runnersSupport/Stabilization
Midsole TechnologyDNA TUNEDDNA TUNED
Upper ConstructionTriple jacquard warp-knitDouble jacquard knit
Diabetic CertificationPDAC A5500PDAC A5500
APMA SealYesnull
PredecessorGlycerin 22Glycerin GTS 21
Support SystemnullGuideRails

Dimension comparison

Brooks Women’s Glycerin GTS 22Brooks Women’s Glycerin 23 Neutral

Introduction and Overview

When selecting the right running shoe, understanding the specific differences between models is crucial for performance and comfort. This comparison examines the Brooks Women's Glycerin GTS 22 and the Brooks Women's Glycerin 23 Neutral. Both shoes belong to the prestigious Glycerin line, known for plush cushioning and smooth transitions. However, they target slightly different needs within the running community. The Brooks Women's Glycerin GTS 22 is positioned at a higher price point, suggesting premium features, while the Brooks Women's Glycerin 23 Neutral offers a more accessible entry price. Both utilize DNA TUNED technology, but their construction and support mechanisms vary.

Cushioning Technology

At the heart of both shoes lies the DNA TUNED midsole technology. This nitrogen-infused foam is designed to adapt to the runner's stride. The Brooks Women's Glycerin GTS 22 features an upgraded version of this midsole, specifically noting 2mm more cushioning in the forefoot. This adjustment aims to create softer landings and more responsive toe-offs. In contrast, the Brooks Women's Glycerin 23 Neutral utilizes cutting-edge cushion technology with larger cells in the heel for plush landings and smaller cells in the forefoot for responsive toe-offs. Both approaches seek a balance of luxury and energy, but the specific tuning differs slightly in execution.

Support and Stability Features

Stability is a key differentiator between these two models. The Brooks Women's Glycerin 23 Neutral explicitly features the innovative GuideRails holistic support system. This system supports the body in its natural motion path while keeping excess movement in check, making it ideal for runners who need stabilization without heavy posting. The documentation for the Brooks Women's Glycerin GTS 22 describes it as suitable for neutral runners seeking premium comfort. While the GTS naming convention typically implies support, the provided specifications highlight neutral performance, suggesting a focus on smooth transitions rather than corrective stability mechanisms found in the other model.

Upper Design and Fit

The upper construction plays a vital role in comfort and breathability. The Brooks Women's Glycerin GTS 22 boasts a newly enhanced triple jacquard warp-knit upper. This design delivers a plush, comfortable fit with the right amount of stretch and structure. It is engineered to wrap the foot securely while reducing hot spots. On the other hand, the Brooks Women's Glycerin 23 Neutral features a newly engineered double jacquard knit upper. While still accommodating and breathable, the triple knit construction of the former suggests a potentially more premium feel and durability, contributing to the price difference between the two shoes.

Certification and Accessibility

Medical certifications can be a deciding factor for runners with specific health needs. Both shoes are certified PDAC A5500 Diabetic shoes, ensuring they meet stringent requirements for therapeutic footwear. However, the Brooks Women's Glycerin GTS 22 goes a step further by granting the APMA Seal of Acceptance. This additional endorsement from the American Podiatric Medical Association indicates a higher level of verification regarding foot health benefits. The Brooks Women's Glycerin 23 Neutral holds the diabetic certification but does not list the APMA seal in the provided specifications, making the former a stronger candidate for those requiring verified medical-grade footwear.

Performance and Use Cases

Both shoes are designed for road running, daily training, and recovery days. The Brooks Women's Glycerin GTS 22 is marketed towards neutral runners seeking premium comfort for long runs. Its adaptive foam supports consistent performance across longer distances. The Brooks Women's Glycerin 23 Neutral is ideal for road running, cross training, or gym use, thanks to its stabilization features. The GuideRails system helps keep excess motion at bay, which can be beneficial for varied activities beyond straight-line running. Runners should choose based on whether they prioritize pure cushioning or motion management during their workouts.

Price and Value

Price is often the most tangible differentiator for consumers. The Brooks Women's Glycerin GTS 22 is listed at $159.99, reflecting its premium upper construction and additional certifications. The Brooks Women's Glycerin 23 Neutral is priced at $114.95, offering a significant saving of over $40. While the former offers a triple knit upper and APMA seal, the latter provides GuideRails support technology at a lower cost. For budget-conscious runners who still want high-quality DNA TUNED cushioning and support features, the lower-priced option presents a compelling value proposition without sacrificing core performance technologies.

Final Recommendation

Choosing between these models depends on specific priorities regarding budget, support, and certifications. If you require the APMA Seal of Acceptance and prefer a triple knit upper for maximum plushness, the Brooks Women's Glycerin GTS 22 is the superior choice despite the higher cost. However, if you value cost efficiency and need the GuideRails support system for stability, the Brooks Women's Glycerin 23 Neutral is the winner. It delivers essential premium features like DNA TUNED cushioning at a much more accessible price point, making it the better overall value for most runners seeking comfort and support.