ALTRA Women's Escalante 4 Road Running Shoe, vs Brooks Women’s Glycerin 22 Neutral Running Shoe -
Updated August 2026 — ALTRA Women's Escalante 4 Road Running Shoe, wins on flexibility, Brooks Women’s Glycerin 22 Neutral Running Shoe - wins on support and breathability.
The Brooks Women’s Glycerin 22 offers superior cushioning and support, making it a better choice for those prioritizing comfort during runs.
Why ALTRA Women's Escalante 4 Road Running Shoe, is better
Price
ALTRA is $6.55 cheaper.
Flexibility
Escalante 4 has a more flexible midsole.
Foot Health
Escalante 4 promotes good foot health with APMA Seal.
Why Brooks Women’s Glycerin 22 Neutral Running Shoe - is better
Cushioning
Glycerin 22 features advanced DNA Tuned cushioning.
Popularity
Glycerin 22 has a better sales rank.
Support
Glycerin 22 provides maximum cushioning and stability.
Overall score
Specifications
| Spec | ALTRA Women's Escalante 4 Road Running Shoe, | Brooks Women’s Glycerin 22 Neutral Running Shoe - |
|---|---|---|
| Brand | ALTRA | Brooks |
| Model | Escalante 4 | Glycerin 22 |
| Midsole | Altra EGO | DNA Tuned |
| APMA Seal | Yes | Yes |
| Sales Rank | 10519 | 844 |
Dimension comparison
Overview of the ALTRA Women's Escalante 4 and Brooks Women’s Glycerin 22
The ALTRA Women's Escalante 4 is priced at $108.40, while the Brooks Women’s Glycerin 22 comes in at $114.95, making the Escalante 4 about 6% cheaper. Both shoes are designed for running but cater to slightly different preferences in fit and technology. The Escalante 4 focuses on a natural feel and comfort, while the Glycerin 22 emphasizes cushioning and support.
Design and Aesthetics
When comparing the design and aesthetics of the ALTRA Women's Escalante 4 and Brooks Women’s Glycerin 22, the Escalante offers a clean, minimalist look in a white color scheme, which can appeal to those who prefer a simple style. On the other hand, the Glycerin 22 features a more colorful combination of white, limpet shell, and amparo blue, potentially attracting runners who enjoy a vibrant appearance. Both styles are visually appealing, but your choice may depend on personal taste and how each shoe complements your running attire.
Comfort and Fit
In terms of comfort and fit, the ALTRA Women's Escalante 4 is designed with an Altra EGO midsole foam that connects the runner with the ground while maintaining comfort. Its InnerFlex midsole provides flexibility and movement. The Brooks Women’s Glycerin 22, on the other hand, incorporates DNA Tuned cushioning technology, which blends dual-size cells for a luxurious feel and smooth transitions. While both shoes promote comfort, the Glycerin 22 may be better suited for those seeking plush cushioning and a more accommodating fit, especially during longer runs.
Performance and Support
Performance-wise, the ALTRA Women's Escalante 4 has received the American Podiatric Medical Association (APMA) Seal of Acceptance, indicating it promotes good foot health. The Brooks Women’s Glycerin 22 also boasts the APMA Seal and provides neutral support with a focus on maximum cushioning. The Glycerin 22's design aims for smooth transitions, making it ideal for varied activities, including road running and cross-training. If you prioritize foot health and flexibility, the Escalante 4 could be a better fit, while the Glycerin 22 excels in providing substantial cushioning and stability.
Technology and Features
The ALTRA Women's Escalante 4 employs innovative features such as the InnerFlex midsole that allows for better flexibility, enhancing overall performance. Conversely, the Brooks Women’s Glycerin 22 showcases more advanced technology with its DNA Tuned cushioning that adapts to each footfall, providing a blend of soft landings and responsiveness. Both shoes highlight modern technology aimed at improving the running experience, but the Glycerin 22 stands out for its luxurious cushioning, which is particularly beneficial for runners seeking extra support during their workouts.
Price Comparison
The ALTRA Women's Escalante 4 is available for $108.40, while the Brooks Women’s Glycerin 22 costs $114.95, representing a price difference of about $6.55. This makes the Escalante 4 approximately 6% less expensive than the Glycerin 22. While price can be a significant factor for many buyers, it’s essential to consider the features and performance each shoe offers to determine which one provides better value for your specific needs.
Sales Rank and Popularity
In terms of sales rank, the Brooks Women’s Glycerin 22 is the more popular choice, ranking at 844 compared to the ALTRA Women's Escalante 4, which has a sales rank of 10,519. This suggests that more consumers are choosing the Glycerin 22, possibly due to its reputation for comfort and support. If popularity and community feedback are essential factors for you, the Glycerin 22 may be the more appealing option.
Which should you buy?
Ultimately, the choice between the ALTRA Women's Escalante 4 and the Brooks Women’s Glycerin 22 depends on your personal preferences and running style. If you prefer a shoe that offers a natural feel with significant flexibility and comfort, the Escalante 4 at $108.40 is a solid choice. However, if you are looking for superior cushioning and support for various activities and are willing to spend a bit more at $114.95, the Glycerin 22 may be the better option. Consider what aspects are most important to your running experience when making your decision.

