Brooks Women’s Adrenaline GTS 25 Supportive vs Brooks Women’s Glycerin 22 Neutral Running Shoe -
Updated July 2026 — Brooks Women’s Adrenaline GTS 25 Supportive wins on price and support, Brooks Women’s Glycerin 22 Neutral Running Shoe - wins on sales rank and weight.
The Brooks Women’s Adrenaline GTS 25 is the better choice for those needing support, while the Glycerin 22 is ideal for those seeking cushioning and a lower price.
Why Brooks Women’s Adrenaline GTS 25 Supportive is better
Price
Adrenaline GTS 25 offers more support features.
Support
GuideRails system provides enhanced stability.
Sales Rank
Adrenaline GTS 25 is more popular among runners.
Why Brooks Women’s Glycerin 22 Neutral Running Shoe - is better
Price
Glycerin 22 is cheaper by $18.
Cushioning
DNA Tuned technology offers luxurious feel.
Weight
Glycerin 22 is likely lighter and more responsive.
Overall score
Specifications
| Spec | Brooks Women’s Adrenaline GTS 25 Supportive | Brooks Women’s Glycerin 22 Neutral Running Shoe - |
|---|---|---|
| Brand | Brooks | Brooks |
| Model | Adrenaline GTS 25 | Glycerin 22 |
| Cushioning | DNA LOFT v3 | DNA Tuned |
| Support Type | GuideRails | Neutral |
| Upper Material | Engineered Mesh | Double Jacquard Knit |
Dimension comparison
Price Comparison
The Brooks Women’s Adrenaline GTS 25 is priced at $132.99, while the Brooks Women’s Glycerin 22 comes in at $114.95. This makes the Glycerin 22 about 13.5% cheaper than the Adrenaline GTS 25. If budget is a significant factor in your shoe choice, the Glycerin 22 offers a more economical option without sacrificing quality.
Intended Use
The Adrenaline GTS 25 is designed for runners and walkers who require reliable support and a smooth ride. It features holistic GuideRails for enhanced support, making it suitable for those who may need stability during their runs. In contrast, the Glycerin 22 is primarily a neutral shoe that emphasizes cushioning and smooth transitions, ideal for road running and cross-training. Depending on whether you need support or prefer a neutral stance, each shoe caters to different activities and runner profiles.
Cushioning Technology
When it comes to cushioning, the Adrenaline GTS 25 utilizes nitrogen-infused DNA LOFT v3 cushioning, which provides a soft, dynamic feel for comfort over long distances. The Glycerin 22, on the other hand, employs DNA Tuned technology, which blends dual-size cells for plush landings and energetic toe-offs. Both technologies are advanced and cater to comfort, but the Adrenaline GTS 25’s cushioning is specifically designed for those needing extra support, whereas the Glycerin 22 focuses on delivering a luxurious feel with its neutral cushioning.
Support Features
The Adrenaline GTS 25 is equipped with the innovative GuideRails holistic support system, which helps manage excess movement from heel to knee, making it particularly beneficial for runners who require additional support. The Glycerin 22 features neutral support with no additional stability elements, making it suitable for those with a neutral foot motion. Hence, if you tend to overpronate or need stability, the Adrenaline GTS 25 is a better fit, while the Glycerin 22 is excellent for those who prefer a more straightforward, cushioned experience.
Fit and Comfort
Both shoes prioritize comfort and fit, but they approach it differently. The Adrenaline GTS 25 has a breathable engineered mesh upper designed to provide a secure fit while allowing for natural movement. The Glycerin 22 features a newly engineered double jacquard knit upper that offers flexibility and exceptional breathability, accommodating various foot shapes. While both shoes aim for comfort, the Adrenaline GTS 25 may be more suited for those who require a snugger fit due to its structural design.
Weight and Transition
The Adrenaline GTS 25 is slightly heavier due to its added support features, which can be a consideration for runners focused on speed. However, its specially designed outsole promotes smooth transitions, ensuring a comfortable running experience. The Glycerin 22, with its broad platform and DNA Tuned cushioning, also provides smooth, stable transitions but is likely to feel lighter and more responsive during runs. Depending on your running style, the weight difference may influence your choice.
Sales and Popularity
The Adrenaline GTS 25 has a bestseller rank of 459, indicating its popularity among runners seeking supportive footwear. The Glycerin 22, with a rank of 844, still enjoys a solid reputation but may not be as widely purchased. While both shoes are reputable, the Adrenaline GTS 25 appears to be the preferred choice for runners who prioritize support and stability, while the Glycerin 22 caters to those who seek luxury and comfort.
Which should you buy?
The choice between the Brooks Women’s Adrenaline GTS 25 and the Glycerin 22 ultimately depends on your specific needs as a runner. If you need a supportive shoe with advanced stability features, the Adrenaline GTS 25 is the clear winner, priced at $132.99. However, if you prefer a neutral running shoe that offers superior cushioning and is more budget-friendly at $114.95, the Glycerin 22 is an excellent choice. Both shoes are high-quality options from Brooks, but understanding your running style and foot support needs will guide you to the right selection.

