Brooks Women’s Glycerin 21 Neutral Running Shoe - vs Brooks Women’s Glycerin 23 Neutral Running Shoe -
Updated August 2026 — Brooks Women’s Glycerin 23 Neutral Running Shoe - leads on cushioning and fit.
The Brooks Glycerin 23 offers enhanced comfort and features, making it the superior choice for serious runners, while the Glycerin 21 provides great value for budget-conscious buyers.
Why Brooks Women’s Glycerin 21 Neutral Running Shoe - is better
Price
Glycerin 21 is $114.95, cheaper than Glycerin 23 at $159.99.
Weight
Glycerin 21 is lighter than Glycerin 23.
Classic Design
Glycerin 21 has a more understated color scheme.
Why Brooks Women’s Glycerin 23 Neutral Running Shoe - is better
Cushioning
Glycerin 23 features zonal DNA Tuned cushioning for better comfort.
Upper Material
Glycerin 23 has a triple jacquard warp-knit upper for improved fit.
Performance
Glycerin 23 is certified as a PDAC A5500 Diabetic shoe.
Overall score
Specifications
| Spec | Brooks Women’s Glycerin 21 Neutral Running Shoe - | Brooks Women’s Glycerin 23 Neutral Running Shoe - |
|---|---|---|
| Brand | Brooks | Brooks |
| Model | Glycerin 21 | Glycerin 23 |
| ASIN | B0CGYG7NL2 | B0F5N9NTJ6 |
| Sales Rank | 29881 | 4982 |
| APMA Seal | Yes | Yes |
Dimension comparison
Overview of the Brooks Glycerin Line
When comparing the Brooks Women’s Glycerin 21 Neutral Running Shoe and the Brooks Women’s Glycerin 23 Neutral Running Shoe, the key difference lies in their price and features. The Glycerin 21 is priced at $114.95, making it about 28% cheaper than the Glycerin 23, which retails for $159.99. This price disparity reflects the advancements and enhancements made in the newer model.
Design and Aesthetics
The design of the Glycerin 21 features a classic color scheme of black, grey, and white, appealing to those who prefer a more understated look. In contrast, the Glycerin 23 showcases a vibrant white, phantom, and cyber pink combination, attracting runners who enjoy a pop of color in their footwear. Both shoes are engineered with an internal bootie for a plush fit, but the 23's upper is enhanced with a triple jacquard warp-knit, offering even more comfort and a modern aesthetic.
Comfort and Fit
The Glycerin 21 is designed for runners seeking a super-soft cushioning experience, boasting nitrogen-infused DNA Loft v3 cushioning. This model provides a plush internal fit and smooth transitions. Meanwhile, the Glycerin 23 takes comfort a step further with its zonal DNA Tuned cushioning, which adds 2mm of cushioning in the forefoot for softer landings and more responsive toe-offs. Both shoes receive high praise for their comfort, but the Glycerin 23 is tailored for those who prioritize a luxurious feel during long runs.
Performance and Support
Performance-wise, both models cater to neutral runners, offering maximum cushioning and support. The Glycerin 21 has been recognized with the APMA Seal of Acceptance, indicating it meets certain health and comfort standards. The Glycerin 23 also carries this seal and is additionally certified as a PDAC A5500 Diabetic shoe, providing an extra layer of assurance for those with specific health needs. While the Glycerin 21 is suitable for various activities, the 23 is specifically designed for premium comfort during long-distance runs.
Transition and Stability
The transition and stability features are key components of both shoes. The Glycerin 21 promotes smooth heel-to-toe transitions thanks to its broad platform. Similarly, the Glycerin 23 enhances this experience through strategic midsole sculpting, allowing for balanced movement. Both shoes ensure that runners can experience a fluid running motion, but the Glycerin 23's design improvements may cater better to those who frequently engage in high-mileage activities.
Durability
Durability is another important factor to consider when comparing these two models. The Glycerin 21 is built with a focus on responsive and durable cushioning, while the Glycerin 23 takes durability up a notch with its updated midsole materials designed to withstand high-mileage usage. Although both shoes are engineered for longevity, the advancements in the Glycerin 23 may offer greater resilience for regular runners.
Pricing and Value
In terms of pricing, the Glycerin 21 is priced at $114.95, while the Glycerin 23 is significantly higher at $159.99. This price difference of about $45 may be a crucial deciding factor for budget-conscious consumers. While both shoes provide excellent features, the value proposition of the Glycerin 21 may appeal more to those looking for quality running shoes without a hefty price tag.
Which should you buy?
Choosing between the Brooks Women’s Glycerin 21 and the Brooks Women’s Glycerin 23 largely depends on your running needs and budget. If you are looking for a more affordable option with solid cushioning and support, the Glycerin 21 is an excellent choice at $114.95. However, if you prioritize the latest advancements in comfort, fit, and performance, and are willing to invest more, the Glycerin 23 at $159.99 may be worth the splurge. Both models are designed to provide a great running experience, but your individual preferences and budget will ultimately guide your decision.

