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Brooks Women’s Glycerin 22 Neutral Running Shoe - vs Nike Women's Pegasus 41 White/White/Pure

Updated August 2026 — Brooks Women’s Glycerin 22 Neutral Running Shoe - wins on cushioning and comfort, Nike Women's Pegasus 41 White/White/Pure wins on weight and breathability.

The Brooks Women’s Glycerin 22 excels in cushioning and comfort, while the Nike Women's Pegasus 41 offers a lighter, more responsive ride. Choose based on your running style.

Why Brooks Women’s Glycerin 22 Neutral Running Shoe - is better

Cushioning

Glycerin 22 features advanced DNA Tuned technology for superior cushioning.

Comfort

Glycerin 22 provides a plush fit ideal for long runs.

Sales Rank

Glycerin 22 has a better sales rank at 844.

Why Nike Women's Pegasus 41 White/White/Pure is better

Price

Pegasus 41 is priced lower at $111.67.

Weight

Pegasus 41 has a lighter design due to engineered mesh.

Responsiveness

Pegasus 41 offers a more responsive ride with dual Air Zoom units.

Overall score

Brooks Women’s Glycerin 22 Neutral Running Shoe -
88
Nike Women's Pegasus 41 White/White/Pure
82

Specifications

SpecBrooks Women’s Glycerin 22 Neutral Running Shoe -Nike Women's Pegasus 41 White/White/Pure
Price$114.95$111.67
Sales Rank84429992
MidsoleDNA TunedReactX Foam
UpperJacquard KnitEngineered Mesh
Support TypeNeutralNeutral

Dimension comparison

Brooks Women’s Glycerin 22 Neutral Running Shoe -Nike Women's Pegasus 41 White/White/Pure

Overview of the Brooks Women’s Glycerin 22 and Nike Women's Pegasus 41

The Brooks Women’s Glycerin 22 is priced at $114.95, while the Nike Women's Pegasus 41 comes in slightly cheaper at $111.67, making it about 3% less expensive. Both shoes cater to women runners looking for comfort and performance, but they differ in design and technology. The Glycerin 22 emphasizes luxurious cushioning with its DNA Tuned technology, while the Pegasus 41 focuses on a responsive ride with its dual Air Zoom units and ReactX foam midsole.

Design and Aesthetics

In terms of design, the Brooks Women’s Glycerin 22 showcases a clean aesthetic with a color palette of White, Limpet Shell, and Amparo Blue. This combination aims to provide a stylish look for various running environments. In contrast, the Nike Women's Pegasus 41 features a more minimalist design in primarily white with elements of Pure Platinum and Metallic Silver. The Pegasus is designed for a lightweight feel, with an upgraded breathable engineered mesh upper that minimizes overall weight while maximizing airflow.

Comfort and Fit

The Brooks Glycerin 22 excels in comfort, offering a plush fit thanks to its engineered double jacquard knit upper, which combines durability and breathability. It features a broad platform that stabilizes the foot, ensuring smooth heel-to-toe transitions. The Nike Pegasus 41, on the other hand, also emphasizes comfort but takes a different approach with its engineered mesh upper that enhances breathability and reduces weight. While both shoes are designed for an accommodating fit, the Glycerin 22 leans more towards providing maximum cushioning, making it ideal for long runs.

Cushioning Technology

Cushioning is a key area where the Brooks Women’s Glycerin 22 stands out due to its DNA Tuned technology. This feature combines larger cells in the heel for plush landings and smaller cells in the forefoot for energetic toe-offs. This innovative design is especially beneficial for runners who prioritize comfort over longer distances. The Nike Women's Pegasus 41 offers responsive cushioning through its ReactX foam midsole and dual Air Zoom units. While both shoes provide distinct cushioning experiences, the Glycerin 22 may appeal more to those seeking softness, while the Pegasus 41 focuses on responsiveness.

Performance and Support

When it comes to performance, the Brooks Glycerin 22 is recognized for its neutral support, making it a versatile choice for various activities, including road running and cross-training. It has a sales rank of 844, indicating its popularity among runners. The Pegasus 41, with a sales rank of 29992, may not have the same level of recognition but still promises an energized ride for everyday road running. With its combination of responsive cushioning and lightweight design, the Pegasus is suitable for shorter runs or faster-paced workouts.

Breathability and Temperature Control

Breathability is crucial for running shoes, and both models address this aspect effectively. The Brooks Glycerin 22's jacquard knit upper provides excellent ventilation, while the Nike Women's Pegasus 41 takes it a step further with its upgraded engineered mesh upper that enhances airflow and reduces weight. This feature can be particularly beneficial during warmer weather, allowing for comfort throughout longer runs. If temperature control is a priority, the Pegasus 41 may have a slight edge due to its focus on lightweight breathability.

Price Comparison

The Brooks Women’s Glycerin 22 comes at a price of $114.95, while the Nike Women's Pegasus 41 is priced at $111.67. This makes the Pegasus about $3.28 cheaper, or roughly 3% less than the Glycerin. If budget is a significant factor in your decision-making, the Pegasus 41 does present a more economical option without sacrificing essential features. However, the choice ultimately depends on which features align more closely with your running style and preferences.

Which should you buy?

Choosing between the Brooks Women’s Glycerin 22 and Nike Women's Pegasus 41 ultimately hinges on your specific running needs. If you prioritize maximum cushioning and a plush fit for longer distances, the Glycerin 22 is the better option, especially given its advanced DNA Tuned technology. However, if you're looking for a lighter, more responsive shoe for everyday road running or quicker-paced workouts, the Pegasus 41 may suit you better, especially at a lower price point. Consider your running style and comfort preferences when making your choice.