Brooks Women’s Glycerin 22 Neutral Running Shoe - vs Saucony Women's Guide 18 Sneaker, White/Mist, 8.5
Updated August 2026 — Brooks Women’s Glycerin 22 Neutral Running Shoe - wins on cushioning and fit, Saucony Women's Guide 18 Sneaker, White/Mist, 8.5 wins on price and support.
The Brooks Women’s Glycerin 22 excels in cushioning and fit, making it ideal for neutral runners, while the Saucony Women’s Guide 18 offers stability for overpronators at a lower price.
Why Brooks Women’s Glycerin 22 Neutral Running Shoe - is better
Cushioning
Glycerin 22 features luxurious DNA Tuned cushioning.
Fit
Glycerin 22 has a more accommodating double jacquard knit upper.
Sales Rank
Glycerin 22 has a higher sales rank of 844.
Why Saucony Women's Guide 18 Sneaker, White/Mist, 8.5 is better
Price
Guide 18 is priced at $99.95, making it more affordable.
Stability
Guide 18 is designed for overpronators, offering better support.
Traction
Guide 18 has a durable rubber outsole for multi-surface grip.
Overall score
Specifications
| Spec | Brooks Women’s Glycerin 22 Neutral Running Shoe - | Saucony Women's Guide 18 Sneaker, White/Mist, 8.5 |
|---|---|---|
| Brand | Brooks | Saucony |
| Price | $114.95 | $99.95 |
| Sales Rank | 844 | 10493 |
| Cushion Type | DNA Tuned | PWRRUN |
| Upper Material | Double Jacquard Knit | Engineered Mesh |
Dimension comparison
Overview of the Brooks Women’s Glycerin 22 Neutral Running Shoe
The Brooks Women’s Glycerin 22 is priced at $114.95 and is designed for runners seeking luxurious cushioning and smooth transitions. This shoe features advanced DNA Tuned midsole technology, which provides both plush landings and energetic toe-offs, making it ideal for various activities, from road running to cross-training. With a sales rank of 844, it is recognized for its quality and performance among neutral support shoes.
Overview of the Saucony Women’s Guide 18 Sneaker
The Saucony Women’s Guide 18 is priced at $99.95, making it about 17% cheaper than the Glycerin 22. This shoe focuses on providing stability and comfort, featuring PWRRUN cushioning for a soft yet responsive ride. Additionally, it has a sales rank of 10,493, indicating it is less popular than the Glycerin 22 but still holds a reputable position in the market for stability shoes.
Comfort and Cushioning
When it comes to comfort, the Brooks Women’s Glycerin 22 excels with its DNA Tuned cushioning, which blends dual-size cells to deliver a plush feel during runs. This shoe is perfect for those who prioritize a soft landing and energetic take-off. In contrast, the Saucony Women’s Guide 18 offers PWRRUN cushioning, which provides a balance of softness and energy return. While both shoes aim for comfort, the Glycerin 22 stands out for its luxurious feel, particularly for runners who value maximum cushioning.
Support and Stability
The Brooks Women’s Glycerin 22 provides neutral support, making it suitable for a wide range of runners. Its broad platform stabilizes the foot, allowing for smooth transitions. On the other hand, the Saucony Women’s Guide 18 is specifically designed for overpronators, offering a stability system that helps correct mild overpronation. This makes the Guide 18 a better choice for runners who require additional support, while the Glycerin 22 is more fitting for those with a neutral gait.
Fit and Breathability
Both shoes offer a comfortable fit, but they achieve it in different ways. The Brooks Women’s Glycerin 22 features a double jacquard knit upper that combines breathability with flexibility, ensuring a snug fit without sacrificing comfort. In comparison, the Saucony Women’s Guide 18 utilizes an engineered mesh upper that enhances ventilation while providing an adaptive fit. While both shoes prioritize breathability, the Glycerin 22 may provide a more accommodating fit for different foot shapes.
Durability and Traction
In terms of durability, the Saucony Women’s Guide 18 shines with its rubber outsole designed for multi-surface grip. This makes it a versatile option for various terrains, from roads to gym floors. The Brooks Women’s Glycerin 22 also features a durable construction that supports its performance, but specific details about its outsole traction are not provided. Therefore, if durability and traction on diverse surfaces are your primary concerns, the Guide 18 may have the edge.
Aesthetic Appeal
The Brooks Women’s Glycerin 22 is available in a stylish color combination of white, limpet shell, and amparo blue, providing a modern look suitable for both running and casual wear. Meanwhile, the Saucony Women’s Guide 18 features a more understated design in white and mist. While aesthetic preferences are subjective, the Glycerin 22 may attract those looking for a more vibrant style, while the Guide 18 caters to those who prefer a simpler look.
Which should you buy?
Choosing between the Brooks Women’s Glycerin 22 and the Saucony Women’s Guide 18 largely depends on your running needs. If you prioritize maximum cushioning and a neutral support experience, the Glycerin 22 is the better option despite its higher price of $114.95. However, if you are looking for a more budget-friendly shoe that offers stability for overpronation, the Guide 18 at $99.95 would be a wise choice. Ultimately, your specific requirements regarding support, comfort, and style will guide your decision.

