Brooks Women’s Ghost 16 Weatherized Neutral vs Brooks Women’s Glycerin GTS 22 Supportive Running
Updated August 2026 — Brooks Women’s Glycerin GTS 22 Supportive Running leads on support and cushioning.
The Brooks Women’s Ghost 16 offers excellent weatherproof features and is more budget-friendly, while the Glycerin GTS 22 provides superior support and cushioning. Choose based on your specific needs.
Why Brooks Women’s Ghost 16 Weatherized Neutral is better
Price
Ghost 16 is $11.72 cheaper
Traction
Better all-weather traction
Weight
Lighter cushioning technology
Why Brooks Women’s Glycerin GTS 22 Supportive Running is better
Support
Features GuideRails for stability
Cushioning
DNA Tuned cushioning for plush feel
Fit
More accommodating double jacquard knit upper
Overall score
Specifications
| Spec | Brooks Women’s Ghost 16 Weatherized Neutral | Brooks Women’s Glycerin GTS 22 Supportive Running |
|---|---|---|
| Brand | Brooks | Brooks |
| Model | Ghost 16 | Glycerin GTS 22 |
| Type | Neutral | Supportive |
| Upper | DWR Mesh | Jacquard Knit |
| Sales Rank | 5547 | 2097 |
Dimension comparison
Overview of the Brooks Women’s Ghost 16 and Glycerin GTS 22
Both the Brooks Women’s Ghost 16 and the Glycerin GTS 22 are exceptional running shoes designed to cater to different types of runners. The Ghost 16 is priced at $103.23, making it about 17% cheaper than the Glycerin GTS 22, which retails for $114.95. While both models share the Brooks brand's reputation for quality, they offer distinct features that may appeal to different preferences and needs.
Design and Aesthetics
When it comes to design, the Ghost 16 features a stylish Almond Peach/Coconut color combination, while the Glycerin GTS 22 showcases a more classic look with its White, Limpet Shell, and Amparo Blue scheme. The Ghost 16 has a weatherized DWR mesh upper that not only looks good but also provides excellent weather protection. In contrast, the Glycerin GTS 22 employs a double jacquard knit upper that emphasizes breathability and flexibility, accommodating various foot shapes. Both shoes are visually appealing, but the choice largely depends on personal taste and the desired functionality.
Comfort and Cushioning
Comfort is a critical factor for any runner, and both models excel in this area. The Ghost 16 features nitrogen-infused DNA Loft v3 cushioning, which ensures a soft and lightweight feel for road running and other activities. Meanwhile, the Glycerin GTS 22 boasts DNA Tuned cushioning technology, offering plush landings with larger cells in the heel and responsive toe-offs with smaller cells in the forefoot. This makes the Glycerin GTS 22 particularly suitable for those who prioritize a luxurious feel in their running experience.
Support and Stability
The Glycerin GTS 22 stands out for its advanced support system. It incorporates the innovative GuideRails technology, which helps stabilize the foot by keeping excess motion in check. This is particularly beneficial for runners who may struggle with overpronation or need additional support during their runs. On the other hand, the Ghost 16 provides neutral support, making it ideal for runners with a neutral gait who do not require additional stability features. Therefore, the choice between these two models may depend heavily on the runner's unique support needs.
Traction and Performance
Both shoes are engineered for optimal performance, but they cater to different conditions. The Ghost 16 excels in all-weather conditions, featuring a specially designed outsole for enhanced wet and dry traction. This makes it a reliable choice for those who often run in varying weather conditions. Conversely, while the Glycerin GTS 22 is also suitable for road running, its focus on smooth transitions and stability may appeal more to runners who prioritize comfort over aggressive traction.
Fit and Sizing
Fit is essential in determining the overall running experience, and both models offer a comfortable fit. The Ghost 16 is available in a 9.5 Medium size, while the Glycerin GTS 22 comes in an 8.5 Medium size. The Glycerin's double jacquard knit upper provides a flexible and accommodating fit, allowing for slight adjustments based on individual foot shapes. The Ghost 16's fit is also commendable, but those requiring a more adaptive fit might lean towards the Glycerin GTS 22.
Price and Value
At $103.23, the Ghost 16 is a more budget-friendly option compared to the Glycerin GTS 22, which is priced at $114.95. The price difference of approximately $11.72 may be significant for budget-conscious consumers. However, value should also be assessed based on the specific needs of the runner. Those looking for enhanced support and features may find the additional cost of the Glycerin GTS 22 worth it, especially considering its bestseller rank of 2097, which indicates a strong preference among consumers.
Which should you buy?
Choosing between the Brooks Women’s Ghost 16 and the Glycerin GTS 22 ultimately depends on your running style and individual needs. If you are looking for a versatile, weatherproof shoe that offers neutral support and excellent traction, the Ghost 16 is an outstanding choice at a lower price point. However, if you need a supportive, cushioned shoe that excels in stability and comfort, the Glycerin GTS 22 may be worth the investment. Both shoes are high-quality options within the Brooks lineup, but your specific requirements will guide you to the right decision.

