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Brooks Women’s Glycerin 21 Neutral Running Shoe - vs Brooks Women’s Glycerin GTS 22 Supportive Running

Updated August 2026 — Brooks Women’s Glycerin GTS 22 Supportive Running leads on sales rank and support.

The Glycerin GTS 22 offers superior support and stability, making it the better choice for runners needing extra assistance. The Glycerin 21 excels in cushioning and comfort for neutral runners.

Why Brooks Women’s Glycerin 21 Neutral Running Shoe - is better

Cushioning

Glycerin 21 features super-soft nitrogen-infused DNA Loft v3 cushioning.

Price

Both shoes are priced the same at $114.95.

Fit

Glycerin 21 has a plush internal fit.

Why Brooks Women’s Glycerin GTS 22 Supportive Running is better

Support

Glycerin GTS 22 includes GuideRails support system.

Sales Rank

Glycerin GTS 22 has a significantly better sales rank.

Cushion Technology

Glycerin GTS 22 uses DNA Tuned cushioning for better stability.

Overall score

Brooks Women’s Glycerin 21 Neutral Running Shoe -
75
Brooks Women’s Glycerin GTS 22 Supportive Running
85

Specifications

SpecBrooks Women’s Glycerin 21 Neutral Running Shoe -Brooks Women’s Glycerin GTS 22 Supportive Running
Price$114.95$114.95
WeightLightLight
Support TypeNeutralSupportive
Cushion TypeDNA Loft v3DNA Tuned
Upper MaterialWarp KnitDouble Jacquard

Dimension comparison

Brooks Women’s Glycerin 21 Neutral Running Shoe -Brooks Women’s Glycerin GTS 22 Supportive Running

Overview of the Brooks Glycerin 21 and Glycerin GTS 22

The Brooks Women’s Glycerin 21 and the Glycerin GTS 22 are both priced at $114.95, making them equally accessible for runners. However, they cater to different types of runners with varying needs for support and cushioning. The Glycerin 21 is designed for neutral runners seeking plush comfort, while the Glycerin GTS 22 provides added support through the innovative GuideRails system aimed at reducing excess motion.

Cushioning and Comfort

The Glycerin 21 features super-soft nitrogen-infused DNA Loft v3 cushioning, which is optimized for a lightweight and responsive feel. This shoe is perfect for runners who prioritize supreme softness and comfort during their runs. Its plush internal fit ensures that the shoe adapts well to the foot's movements. In contrast, the Glycerin GTS 22 boasts DNA Tuned cushioning that combines larger heel cells for soft landings with smaller forefoot cells for energetic toe-offs. While both shoes provide excellent cushioning, the Glycerin GTS 22 may be better suited for those who require a bit more stability without sacrificing comfort.

Support and Stability

The primary difference between the two shoes lies in their support systems. The Glycerin 21 offers neutral support, making it ideal for runners who do not overpronate. On the other hand, the Glycerin GTS 22 is equipped with the GuideRails holistic support system, which helps keep excess motion at bay and supports the body's natural movement path. This additional feature is particularly beneficial for runners who need extra stability during their runs, making the Glycerin GTS 22 a more suitable choice for those with specific stability needs.

Fit and Breathability

When it comes to fit, both shoes are designed to provide a comfortable experience. The Glycerin 21 features an internal stretch bootie that accommodates the foot's natural movements, while the newly engineered warp knit upper enhances breathability. Meanwhile, the Glycerin GTS 22 includes a double jacquard knit upper that offers a flexible and accommodating fit. Both shoes excel in providing breathability, but the Glycerin GTS 22's design may offer slightly better durability in extended use, thanks to its emphasis on a robust construction.

Versatility for Activities

Both the Glycerin 21 and Glycerin GTS 22 are versatile enough for various activities, such as road running, cross-training, and gym workouts. This adaptability is essential for runners who may not stick to a single workout style. The Glycerin 21, with its neutral support and plush cushioning, is an excellent choice for those who enjoy long-distance running or prefer a softer feel. Conversely, the Glycerin GTS 22, with its added stability features, is ideal for runners who may engage in more intense workouts or require a shoe that can handle a variety of terrains.

Sales Performance

In terms of sales rank, the Glycerin GTS 22 outperforms the Glycerin 21, holding a position of 2097 compared to the Glycerin 21's 29881. This suggests that the Glycerin GTS 22 is more popular among consumers, possibly due to its supportive features appealing to a broader audience. The higher sales rank indicates a stronger market presence, which might be an essential factor for buyers looking for a shoe that many others trust and recommend.

Aesthetic Appeal

Both shoes come in stylish color options, but they cater to different aesthetic preferences. The Glycerin 21 is available in a classic black, grey, and white combination, making it a versatile choice for various outfits. In contrast, the Glycerin GTS 22 features a more vibrant palette with white, limpet shell, and amparo blue, appealing to those who prefer a more eye-catching design. The choice of color may influence which shoe resonates more with individual style preferences, but both maintain a sleek and modern look.

Which should you buy?

Choosing between the Brooks Women’s Glycerin 21 and Glycerin GTS 22 comes down to your specific running needs. If you are a neutral runner looking for maximum cushioning and comfort, the Glycerin 21 is the better option. However, if you require additional support and stability during your runs, the Glycerin GTS 22 would be the more suitable choice. Both shoes are priced at $114.95, so your decision should hinge on your support requirements and personal aesthetic preferences.