Brooks Women’s Glycerin GTS 22 Supportive Running vs Nike Women's Run Defy Road Running Shoes,
Updated August 2026 — Brooks Women’s Glycerin GTS 22 Supportive Running leads on support and cushioning.
The Brooks Women’s Glycerin GTS 22 offers superior support and cushioning, making it ideal for serious runners, while the Nike Women’s Run Defy is a more budget-friendly option for casual use.
Why Brooks Women’s Glycerin GTS 22 Supportive Running is better
Price
Brooks offers advanced technology justifying its higher price.
Support
Brooks features GuideRails for enhanced stability.
Cushioning
Brooks has DNA Tuned cushioning for a plush ride.
Why Nike Women's Run Defy Road Running Shoes, is better
Affordability
Nike is significantly cheaper.
Weight
Nike is lighter, appealing for speed.
Simplicity
Nike is a straightforward option for casual runners.
Overall score
Specifications
| Spec | Brooks Women’s Glycerin GTS 22 Supportive Running | Nike Women's Run Defy Road Running Shoes, |
|---|---|---|
| Brand | Brooks | Nike |
| Current Price | $114.95 | $65.00 |
| Sales Rank | 2097 | 11383 |
| Cushion Type | DNA Tuned | Foam |
| Upper Material | Double Jacquard Knit | Mesh |
Dimension comparison
Price Comparison
The Brooks Women’s Glycerin GTS 22 is priced at $114.95, while the Nike Women’s Run Defy Road Running Shoes are significantly more affordable at $65.00. This makes the Nike option about 43% cheaper than the Brooks model. For budget-conscious shoppers, the lower price point of the Nike shoes may be more appealing, especially considering that both are designed for running. However, the price difference reflects some of the technological advancements found in the Brooks model, which may justify the higher cost for serious runners looking for enhanced support and cushioning.
Design and Aesthetics
In terms of design, the Brooks Women’s Glycerin GTS 22 features a sleek aesthetic with a combination of white, limpet shell, and amparo blue. This colorway appeals to those who appreciate a modern look while maintaining functionality. On the other hand, the Nike Women’s Run Defy showcases a classic white and pure platinum-black scheme. While both shoes are visually appealing, the Brooks model's double jacquard knit upper indicates a focus on both durability and breathability, which may attract runners seeking a blend of style and performance.
Comfort and Fit
The Brooks Women’s Glycerin GTS 22 excels in comfort, offering a DNA Tuned cushion system that provides luxurious cushioning for a smooth ride. This model also includes an accommodating fit due to its engineered upper, designed to ensure breathability and flexibility. In contrast, the Nike Women’s Run Defy features a foam midsole for a soft ride; however, it lacks the advanced cushioning technology found in the Brooks. While the Nike shoe provides decent comfort, it may not match the plush feel that serious runners might expect from the Brooks model.
Support and Stability
Support is a key differentiator between these two models. The Brooks Women’s Glycerin GTS 22 includes the innovative GuideRails support system, which helps stabilize the foot and minimizes excess motion. This technology is particularly beneficial for runners who require additional support during their runs. Conversely, the Nike Women’s Run Defy offers basic support with a flexible foam midsole and a durable waffle outsole. While it provides a good running experience, it may not deliver the same level of stability that the Brooks shoe offers, making it less suitable for those with specific support needs.
Performance on Different Terrains
Both shoes are designed for road running, but the performance characteristics differ. The Brooks Women’s Glycerin GTS 22 is ideal for various running scenarios, including cross-training, thanks to its broad platform and smooth heel-to-toe transitions. This versatility makes it a great choice for runners who participate in multiple activities. The Nike Women’s Run Defy, while also suitable for road running, is more basic in its performance features. It includes flex grooves that create a cushioned effect, but it may not handle diverse terrains as effectively as the Brooks option.
Breathability
When it comes to breathability, the Brooks Women’s Glycerin GTS 22 is engineered with a double jacquard knit upper, enhancing airflow to keep feet cool during longer runs. This feature is particularly beneficial for warmer conditions or intense workouts. The Nike Women’s Run Defy also incorporates mesh in its upper design, promoting breathability. However, the advanced construction of the Brooks model likely provides a superior experience for runners who prioritize ventilation in their running shoes.
Weight and Agility
Weight can significantly impact running performance. While exact weights are not provided, the Brooks Women’s Glycerin GTS 22 is designed to offer a plush ride that might add a bit more weight compared to the lighter Nike Women’s Run Defy. The latter's focus on a flexible, lightweight design may appeal to runners looking for agility during shorter runs or speed training. However, those prioritizing cushioning and support may find the slight increase in weight of the Brooks to be a worthy trade-off for the enhanced comfort it provides.
Which should you buy?
Choosing between the Brooks Women’s Glycerin GTS 22 and the Nike Women’s Run Defy ultimately depends on your running needs and budget. If you are looking for a shoe that offers advanced support, cushioning, and versatility for various activities, the Brooks model is worth the investment at $114.95. However, if you are on a tighter budget or prefer a more basic running shoe for occasional use, the Nike Women’s Run Defy at $65.00 is a solid choice. Both shoes serve their purpose well, but they cater to different types of runners.

